The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming
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چکیده
منابع مشابه
The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and ...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2014
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2014.09.008